Chiefs vs. 49ers Odds, Tips & Predictions – NFL Week 7

America’s Game of the Week features a repeat of Super Bowl 54 as Kansas City visits Levi’s Stadium to take on San Francisco. Find out why we’re backing the road team on Sunday in our Chiefs vs. 49ers betting tips.

Week 7 of the NFL season is already here, and we have a great out-of-conference matchup as the 4-2 Kansas City Chiefs take on the 3-3 San Francisco 49ers.

Both sides participate in this competition by taking hard losses. Kansas City suffered a 24-20 home loss to the Buffalo Bills, and the Atlanta Falcons doubled the 49ers’ score in the Niners’ away loss to the Falcons. Who will win this marquee matchup?

Find out in our free NFL picks and predictions for this Sunday, October 23 showdown between the Kansas City Chiefs and the San Francisco 49ers.

Be sure to check out Phil Naessen’s full match betting analysis before kick-off!

Chiefs vs 49ers best odds

Chiefs vs. 49ers tips and predictions

We have a replay of their Super Bowl 54 meeting that Kansas City won in exciting fashion. I was thinking of just playing the money line on Sunday, but the Chiefs are going to win this game by more than a point.

Chiefs quarterback Patrick Mahomes will try to recover from a tough home loss to the Bills. He threw a pair of interceptions for 338 yards and a couple of touchdowns against one of the best defenses in the game. Mahomes is third in passing yards and his 17 TD passes tie with Josh Allen for the league’s top spot.

Mahomes likely misses former teammate Tyreek Hill, but tight end Travis Kelce has picked up the extra slack and leads the team with seven TD receptions. Offseason acquisition JuJu Smith-Schuster got his first TD reception in the loss to the Bills, and wideouts Mecole Hardman and Marquez-Valdes Scantling are having decent seasons.

The San Francisco 49ers defense ranks 3rd overall on the DVOA but 7th on the pass. They allowed four TDs against Atlanta last week, and Kansas City will see the toughest competition this season. CB Chavarious Ward and SS Talanoa Hufanga are both doubtful and Mahomes will have an easier time without those two.

Niners’ QB Jimmy Garoppolo was steady, throwing for 1,153 passing yards, seven TDs and three interceptions. Deebo Samuel leads the team in goals with an additional 136 rushing yards and a TD. Brandon Aiyuk leads the team with three TD receptions and TE George Kittle saw 10 goals last week.

The Chiefs defensive DVOA is ugly. They rank 28th overall with better fast defense than passing defense, which has more to do with opponents looking at the scoreboard than anything else. CB Rashad Fenton is out on Sunday which should make it easier for Jimmy G to find Aiyuk or Samuel for a big one.

This competition has all the makings of a shootout. Kansas City has had a demanding schedule so far, and Mahomes and company won’t be the least bit fazed by the 49ers’ defense. Look for the Chiefs QB to rely on Kelce and the Niners’ battered defense will find it difficult to hold a duo who have linked for 42 goals since 2018.

San Francisco will respond in kind, but the 49ers’ offense is average at best, and that won’t be enough to outsell as many points as their defense allows for Kansas City.

my best bet: Chiefs -1 (-110 at Caesars)

Chiefs vs. 49ers spread analysis

I’m going with Chiefs -2.5, but here are some additional notes I have for the side bet. The Chiefs have lost two of their last four games, which doesn’t do Andy Reid any good.

Since 2013, Reid and the Chiefs have held 23-20 against the spread and 29-20 as away favorites after a loss. 49ers running back Jeff Wilson did an excellent job of leading football with the 12th most rushing yards in the league.

Chiefs RB Clyde Edwards-Helaire ran for 92 yards against Tampa Bay but hasn’t had more than 10 carries since. He’s a little battered but was involved in the passing game with a TD reception.

The Chiefs don’t need big numbers from their RB to succeed, but a strong rushing attack would help set Mahomes up for greater success. Mahomes is 13-2-1 ATS when favored by three points or fewer.

Chiefs vs. 49ers Over/Under Analysis

The 49-point total looks a bit low for this one, and I’m leaning towards the over.

The 49ers’ defense allowed 28 points down the road against the Falcons, which worried me a bit. That’s double their average allowable points, and the No. 1 Chiefs’ offense may be slightly better than Atlanta’s.

Kansas City has the 19th most total yards allowed in the game, along with the 24th points allowed. Look for Garoppolo and Samuel to connect multiple times against a soft pass defense that allows for 2.5 TDs per fight. San Francisco has averaged 29.3 points in its three wins this season but just 11 points in its three losses.

This week, the 49ers acquired RB Christian McCaffrey from the Carolina Panthers. He’s an Impact player but we’re not sure what he will or won’t do on Sunday.

Chiefs vs. 49ers betting trend you should know

Kansas City is 5-1 ATS in its last six games. Find more NFL betting trends for Chiefs vs 49ers.

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