How does a healthy lifestyle counteract the genetic predisposition to type 2 diabetes? Read | IWMBuzz

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According to research by Juliana Chan (The Chinese University of Hong Kong, Shatin) and colleagues, self-management, which they defined as maintaining a healthy lifestyle combined with routine self-monitoring of blood glucose (SMBG), was associated with better control of cardiometabolic risk factors, especially if there is a family history of diabetes.

59.5 percent of the 86,931 patients with type 2 diabetes from 427 clinics in 11 Asian countries or regions between 2007 and 2021 had a parent or sibling with diabetes; However, the frequency varied between 39.1 percent in Vietnam and 85.3 percent in Malaysia. The most commonly affected relative was the mother alone (13.2%), followed by the father alone (9.8%), siblings alone (11.5%), and various combinations of the three.

The researchers discovered that people with a family history were diagnosed significantly 4.6 years earlier than those without a family history, even though the median age at diagnosis of diabetes was 49.8 years (mean 47.9 vs. 52.5 years).

Patients with two affected parents and one or more affected siblings within the family history group had the earliest mean age at diagnosis (44.6 years), followed by patients with one affected parent and one or more affected siblings (47.7 years) and those exclusively with affected siblings (51.5 years). There was a statistically significant difference between the groups.

The researchers discovered that people with a family history of diabetes were more likely to have completed middle school or higher education (82.0 versus 71.6 percent), be employed (48.1 versus 40.4 percent), and perform routine SMBG Tests (73.5 vs. 65.9 percent). However, a healthy lifestyle, such as a balanced diet, abstinence from alcohol and cigarettes and regular physical activity, was mentioned less frequently.

However, a healthy lifestyle, such as a balanced diet, abstinence from alcohol and cigarettes and regular physical activity, was mentioned less frequently. Chan and his company then investigated whether an unhealthy lifestyle and family history work together to increase the age of diagnosis. They discovered that those with a family history and fewer than two recorded healthy lifestyle habits were diagnosed at the median age of 46.0 years at the earliest. With a median age of 52.8 years, those with two or more healthy habits and no family history were the oldest at diagnosis.

It is notable that subjects with a family history of diabetes who reported following two or more healthy lifestyles had a similar mean age at diagnosis as subjects with no family history, but with less healthy lifestyles (48.2 vs. 50, 1 years).

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