Monday Night Football Odds, Spread, Line: Titans vs. Bills Predictions, NFL Picks by the Expert Who’s 23-12

The Tennessee Titans will look to avoid starting the season 0-2 for the first time in a decade when they take on the Buffalo Bills Monday night. Tennessee opened the regular season at home, giving up a 13-point lead at halftime last Sunday en route to a 21-20 loss to the New York Giants. Buffalo, meanwhile, got off to a quick start as the Bills clinched a 31-10 win over the Rams in Los Angeles. Both teams want to repeat their division championships. The Titans have won an AFC South title 12-5 while the Bills have won the AFC East 11-6.

Kick-off from Highmark Stadium in Orchard Park, NY is scheduled for 7:15 p.m. ET. Buffalo is a 10-point favorite in the latest Titans vs. Bills odds from Caesars Sportsbook, while the over/under for total points scored is 47.5. Before committing to Bills vs. Titans, be sure to read SportsLine’s Larry Hartstein’s NFL predictions and betting tips.

A former head writer for Covers and The Linemakers, Hartstein combines a vast network of Vegas sources with an analytical approach he honed while working for Pro Football Focus. As the 2022 NFL season begins, he’s 427-344 all-time on NFL sides (up $3,764 for $100 players), including 394-330 against the spread. Hartstein was 68-50 ATS (58 percent) and 8-3 on money line games last season for a $1,552 win.

Additionally, Hartstein has gone 23-12-1 on his last 36 NFL picks involving the Titans and returned $1,007. Whoever followed him is way up.

Now, Hartstein has set his sights on Titans vs. Bills, laying down his NFL picks and predictions. You can go to SportsLine to see his selection. Here are some NFL odds and trends for Bills vs. Titans:

• Distribution Titans vs. Bills: Buffalo -10
• Titans vs. Bills Over-Under: 47.5 points
• Titans vs. Bills moneyline: Tennessee +360, Buffalo -480
• TEN: The Titans are 8-2 against the spread in their last 10 Monday games
• BUF: Bills comes in as a favorite with 4-0-1 ATS in the last five games
• Titans vs. Bills tips: See tips at SportsLine

Why the bills can cover

Quarterback Josh Allen has made another quick start for Buffalo. Last week, Allen completed 26 of 31 passes (83.9 percent) for 297 yards and three touchdowns in a win over the Rams. He also rushed 10 times for 56 yards and a score. In more than four seasons as the Bills’ QB, Allen has completed 62.6 percent of his passes and has a 91.4 rating. Despite two picks against Los Angeles, Allen compiled a 112 rating in Week 1.

Linebacker Von Miller made himself felt defensively. He had three tackles for loss and two sacks in his Buffalo debut last week. It was his 21st career game with two or more sacks, fourth most among active players. In four career games against Tennessee, Miller has 2.5 sacks and two forced fumbles. Miller had 9.5 sacks in 2021 while he spent time in Denver and with the Los Angeles Rams. He has 117.5 career sacks.

Why the Titans can cover

Quarterback Ryan Tannehill remained steady in Week 1 in the loss to the Giants. He completed 20 of 33 passes (60.6 percent) for 266 yards and two touchdowns for a 106.4 rating. Tannehill comes off a season in which he completed 67.2 percent of his passes and completed 357 of 531 attempts for 3,734 yards and 21 touchdowns. He was intercepted 14 times and had an 89.6 rating. Last year, he had a 106.5 rating with 33 touchdowns and seven picks.

The Titans are strong defensively. Last week, defensive tackle Jeffery Simmons registered two sacks and his second career forced fumbles. It was also his third game with two or more sacks. In Tennessee’s last meeting with Buffalo last October, Simmons recorded a sack in a 34-31 Titans win. During his career, Simmons has 141 tackles, including 88 solo, with two forced fumbles, three fumble recoveries, 15.5 sacks and 12 pass breakups.

How to make Bills vs Titans tips

Hartstein has analyzed this matchup from every angle and while we can tell you he’s leaning over the total, he’s spotted a critical X-Factor that has him jumping all over the side of the range. He only shares at SportsLine what it is and who to support.

So, who will win Bills vs. Titans on Monday Night Football? And what critical X-factor makes one side of the spread a must-back? Visit SportsLine now to see which side of the Bills vs. Titans is splayed backwards, all from the NFL pundit who is 23-12 on picks with Tennessee, and find out.