Earlier diagnosis of diabetes related to younger age in natural menopause

According to study results, women who die before the age of 30

The data were presented at the annual meeting of the North American Menopause Society.

“As more women are being diagnosed with diabetes at younger ages, clinicians need to consider the long-term health implications this will have on their reproductive health, including age at natural menopause.” Vrati M. Mehra, MScan MD candidate at the University of Toronto’s Temerty Faculty of Medicine, told Healio.

Vrati M. Mehra

Mehra and colleagues analyzed baseline data from the Canadian Longitudinal Study on Aging. The study involved 11,436 women diagnosed with type 1 diabetes, type 2 diabetes or gestational diabetes before the menopause. Age at natural menopause was the primary outcome of the analysis. The researchers also calculated the mean age at natural menopause for each type of diabetes.

The mean age of the cohort at natural menopause was 52 years. After adjusting for race, education, smoking, premenopausal factors, and other covariates, women diagnosed with type 1 diabetes less than 30 years of age (adjusted HR = 1.55; 95% CI, 1.05-2 ,29) and women diagnosed with type 2 diabetes between the ages of 30 and 39 years (aHR = 1.82; 95% CI, 1.12–2.95) were more likely to be younger in age natural menopause than women without diabetes. Mehra said the link between type 2 diabetes and age at natural menopause is surprising.

“Based on previous studies, there was some evidence that women with type 1 diabetes may menopause earlier and women with type 2 diabetes may menopause later, since type 2 diabetes is traditionally diagnosed at older ages ‘ said Mehra. “Hence, we did not expect that earlier diagnosis of type 2 diabetes would be significantly related to age at natural menopause.”

No association was found between gestational diabetes and age at natural menopause. Women diagnosed with type 2 diabetes over age 50 were more likely to have had a later age at natural menopause than women without diabetes (aHR = 0.39; 95% CI, 0.27-0, 56).

“We recommend that physicians educate their young patients with type 1 and type 2 diabetes about this possible link between early diagnosis of diabetes and age in natural menopause and are prepared to support their patients in this transition,” said Mehra. “We also don’t know how premenopausal diabetes affects women’s experience of menopausal symptoms such as vasomotor symptoms, but we are all learning how severe these symptoms can be, so we would recommend paying more attention to your patients’ history of diabetes.” and support them in this transition. I must also stress that we need more public health support in the primary prevention of diabetes. We must do our best to contain the growing diabetes epidemic among younger people.”

Mehra said more research is needed to better understand the mechanisms behind diabetes status and age at natural menopause, and to confirm the impact of longstanding diabetes and a history of gestational diabetes on reproductive health.

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North American Menopause Society